Clusters of Orthologous Groups

COGs Phylogenetic classification of proteins encoded in complete genomes

Clusters of Orthologous Groups of proteins (COGs) were delineated by comparing protein sequences encoded in complete genomes, representing major phylogenetic lineages. Each COG consists of individual proteins or groups of paralogs from at least 3 lineages and thus corresponds to an ancient conserved domain.

66 genomes 38 orders 28 classes 14 phyla Unicellular clusters FTP Initial version Science 1997 Oct 24;278(5338):631-7, BMC Bioinformatics 2003 Sep 11;4(1):41. Euryarchaeota Methanobacteriales Mth Methanococcales Mja Halobacteriales Hbs Thermoplasmatales Tac Tvo Thermococcales Pho Pab Archaeoglobales Afu Methanopyrales Mka Methanosarcinales Mac Crenarchaeota Thermoproteales Pya Sulfolobales Sso Desulfurococcales Ape Ascomycota Saccharomycetales Sce Schizosaccharomycetales Spo Microsporidia Apansporoblastina Ecu Aquificae Aquificales Aae Thermotogae Thermotogales Tma Cyanobacteria Nostocales Nos Chroococcales Syn Deinococcus-Thermus Deinococcales Dra Fusobacteria Fusobacterales Fnu Spirochaetes Spirochaetales Tpa Bbu Chlamydiae Chlamydiales Ctr Cpn Actinobacteria Actinomycetales Cgl Mtu MtC Mle Firmicutes Clostridiales Cac Bacillales Sau Lin Bsu Bha Lactobacillales Lla Spy Spn Mycoplasmatales Uur Mpu Mpn Mge Proteobacteria Pseudomonadales Pae Enterobacteriales Eco EcZ Ecs Ype Sty Buc Xanthomonadales Xfa Vibrionales Vch Pasteurellales Hin Pmu Burkholderiales Rso Neisseriales Nme NmA Campylobacterales Hpy jHp Cje Caulobacterales Ccr Rhizobiales Atu Sme Bme Mlo Rickettsiales Rpr Rco Upcoming microbial genomes genomes genera orders classes phyla 261 126 63 33 17 [N] Nano [A] Euryarchaeota (8) * Methanobacteria * Methanococci * Methanomicrobia * Halobacteria * Thermoplasmata * Thermococci * Archaeoglobi * Methanopyri [R] Creno (3) [D] Deinococcus (2) [T] Actinobacteria (3) [P] Proteobacteria (26) α (6) β (5) γ (10) δ (4) ε (1) [O] Other (9) * Bacteroidetes * Chlorobi * Fusobacteria * Aquificae * Chloroflexi * Thermotogae * Planctomycetes * Spirochaetes * Chlamydiae [F] Firmicutes (7) Mollicutes (3) Bacilli (2) Clostridia (2) [C] Cyanobacteria (4) * Gloeobacteria * Nostocali * Prochlorali * Chroococcali

Eukaryotic Clusters FTP Code Name Abbreviation A Arabidopsis thaliana (thale cress) ath C Caenorhabditis elegans (worm) cel D Drosophila melanogaster (fruit fly) dme H Homo sapiens (human) hsa Y Saccharomyces cerevisiae (baker yeast) sce P Schizosaccharomyces pombe (fission yeast) spo E Encephalitozoon cuniculi (Microsporidia) ecu Upcoming eukaryotic genomes O Oryza sativa (rice) osa Q Anopheles gambiae (mosquito) aga Z Pan troglodytes (chimpanzee) ptr W Canis familiaris (dog) cfa M Mus musculus (mouse) mmu R Rattus norvegicus (rat) rno Ascomycota genomes including L Magnaporthe grisea mgr N Neurospora crassa ncr

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